Similarly to the scenario observed in cancer, loss of imprinting of the IGF2‐H19 locus during aging (Fu et al., 2008) may be leading to an abnormal expression of H19, and other genes in this locus, leading to a dysfunctional mobilization of gut stem cells (Grammatikakis, Panda, Abdelmohsen, & Gorospe, 2014). The gene discussed is H19; the disease is cancer.