PDE11A and adrenal cortex carcinoma: Furthermore, in a study aimed at identifying the presence of germline or somatic PDE11A mutations that included 117 subjects with adrenocortical tumors and 195 control subjects, a higher frequency of PDE11A mutations was found in subjects with adrenocortical tumors compared to age/sex matched controls (16% vs 10% in adrenocortical cancer, 19% vs 10% in adrenocortical adenoma, and 24% vs 9% in AIMAH) [15].