In addition, HH signaling has been shown to act in a paracrine manner in PDAC, with tumor-secreted SHH activating the HH pathway in pancreatic fibroblasts (Yauch et al, 2008).These studies, however, did not directly address the potential oncogenic functions of the tumor microenvironment in pancreatic cancer progression. The gene discussed is SHH; the disease is pancreatic neoplasm.