However, recent results have challenged this interpretation, demonstrating in mouse models that ablation of fibroblasts in the pancreatic tumor stroma increases tumor growth and, contrary to previous studies, an independent cohort of patients with tumors having fewer SMA-positive cells had poorer overall survival than those more enriched for SMA-positive cells (Ozdemir et al, 2014). Here, SMN1 is linked to pancreatic neoplasm.