Importantly, in both human and mouse breast tumors, down-regulation of each paralog is associated with a distinct breast cancer subtype and deregulation of different signaling pathways; decreased LATS1 compromises the strict maintenance of luminal cell fate and favors a drift towards a more basal-like state, whereas decreased LATS2 rewires metabolism towards reduced PPARγ activity and increased glycolysis. Here, LATS2 is linked to breast carcinoma.