Metaplastic carcinomas are typically negative of hormone receptors (ER/PR) and HER-2/neu, and are histologically characterized by mixed epithelial and transdifferentiated components (Aydiner et al, 2015), thus resembling the adenosquamous carcinomas detected in the Lats1-CKO PyMT tumors. This evidence concerns the gene ESR1 and adenosquamous carcinoma.