Metaplastic carcinomas are typically negative of hormone receptors (ER/PR) and HER-2/neu, and are histologically characterized by mixed epithelial and transdifferentiated components (Aydiner et al, 2015), thus resembling the adenosquamous carcinomas detected in the Lats1-CKO PyMT tumors. Here, NR4A1 is linked to adenosquamous carcinoma.