Congruous with the changes in ER and CK14 levels in Lats1-CKO PyMT tumors (see Fig 6C and D), the expression pattern of Lats1-CKO PyMT tumors was similar to other ER-negative mouse mammary tumors (Fig 7A) and dissimilar to mature luminal cells (Fig 7B). The gene discussed is LATS1; the disease is breast cancer.