LATS1 and breast cancer: In addition, we derived a basal-like expression signature from human breast cancer samples (TCGA dataset, see the Materials and Methods section) and found it to be up-regulated selectively in the Lats1-CKO PyMT, but not Lats2-CKO tumors (each compared with WT-PyMT littermate control tumors, Fig 7D and Table S3).