Overall, the expression pattern changes in the mouse Lats1-CKO PyMT tumors agreed well with those seen in human luminal cancer cell lines (MCF7 and ZR75-1) subjected to either up- or down-modulation of LATS1 (Fig S6E), supporting the human relevance of the Lats1-CKO PyMT model. The gene discussed is LATS1; the disease is cancer.