Using Vnn1-deficient mice (Pitari et al, 2000), we have previously showed that pantetheinase activity is required for tissue adaptation to stress induced by damage, infection, or inflammation (Naquet et al, 2014) and more specifically during myofibroblast-dependent tissue repair and fibrosis (Dammanahalli et al, 2012; Kavian et al, 2016). The gene discussed is VNN1; the disease is infection.