VNN1 and telomere syndrome: In favor of this hypothesis, an analysis of VNN1 transcriptional profile in a large array of human STS gathered in the Conticabase (Chibon et al, 2010) showed that undetectable level of VNN1 expression (observed in 198 of 349 sarcomas with complex genomics, 57%) is associated with increased risk of metastatic relapse in patients (Fig 1D).