The negatively charged pADPr polymers recruits a large spectrum of proteins (Gagne et al, 2008, 2012), including FET (FUS [fused in liposarcoma], EWS [Ewing sarcoma] and TAF15 [TATA binding associated factor 15]) family proteins FUS and TAF15 that rapidly accumulate at DNA lesions induced by micro-irradiation (Altmeyer et al, 2015; Izhar et al, 2015; Patel et al, 2015). Here, FUS is linked to Ewing sarcoma.