Brain tumors were created by stereotactic intracranial injections of the aforementioned lenti PDGF-A-Cre viruses in adult (>12 wk) LSL-PDGFRα;p532lox mice that were fed a DOX diet (250 mg/kg) ad libitum post-injection (Fig 3B–D). Here, PDGFA is linked to brain neoplasm.