The PDGF-A;PDGFRα;p53−/− tumors displayed histopathological features that are observed in high-grade gliomas, i.e., tumors were densely packed, containing poorly differentiated cells with marked nuclear atypia, numerous giant multinucleated cells, and characteristic areas of pseudopalisading necrosis (Fig 3D). Here, PDGFA is linked to glioma.