Three translation inhibitors, 4EGI-1 (Moerke et al, 2007), LY2584702 (Tolcher et al, 2014), and AZD8055 (Chresta et al, 2010), which target the translation initiation eif4F complex, the p70S6K, and mTORC, respectively (Fig S7), were applied to chronically activated PDGFRα GBM primary cell cultures and cell viability was measured. Here, EIF4E is linked to glioblastoma.