This approach has been used to create detailed signaling maps for epidermal growth factor (EGF) receptor (EGFR) (Oda et al, 2005), mechanistic target of rapamycin (mTOR) (Caron et al, 2010), Rb/E2F pathway (Calzone et al, 2008), toll-like receptor signaling (Oda & Kitano, 2006), and comprehensive molecular interaction maps for budding yeast cell cycle (Kaizu et al, 2010) and rheumatoid arthritis (Wu et al, 2010). Here, MTOR is linked to rheumatoid arthritis.