SYCE2 and cancer: Moreover, induction of SYCE2 expression was observed in the DLD1 and HT1080 cancer cell lines after treatment with the demethylating agent 5-azacytidine (Fig S1D), indicating that SYCE2 expression is regulated by a demethylation-dependent process, as has been described for some cancer-testis antigens (Simpson et al, 2005).