In vitro infection of prostate cancer cell lines with SeV, a model for a wide range of RNA viruses, showed induction of IFN-λ4 in a cell line homozygote for the ΔG allele (PC3) but not in a cell line without this allele (DU145), supporting the hypothesis for a viral origin of IFN-λ4 expression in prostate tissue. This evidence concerns the gene IFNL4 and prostate carcinoma.