Signaling analysis in another triple negative breast cancer cell line, HCC-1143, with a high endogenous expression of RON, also confirmed strong upregulation of AKT, p70S6K, and rpS6 phosphorylation as a result of ligand-dependent RON activation, which could be reversed using the selective RON inhibitor ASLAN002 (Supplementary Figure S6C). The gene discussed is RPS6KB1; the disease is triple-negative breast carcinoma.