The results demonstrated that reduction of KIAA1199 decreased the level of cyclinD1, while the expression of cyclinE, cyclin-dependent kinases 2 (CDK2), and cyclin-dependent kinases 4 (CDK4) were not observably affected in both MHCC-97H (Fig. 4c, d) and HCC-LM3 cells (Fig. 4e, f). The gene discussed is CDK4; the disease is hepatocellular carcinoma.