First, our data together with other studies demonstrated variable prevalence of genetic susceptibility in different paediatric tumours, ranging from <5% in neuroblastoma and Wilms tumour to over 50% in ACC and pheochromocytoma.3,38–40 Second, while tumours such as ACC are strongly correlated with well-known susceptibility genes and CPS, e.g. TP53 and LFS, genetic alterations in tumours that are associated with little-known CPS or susceptibility genes are likely underestimated. This evidence concerns the gene TP53 and neoplasm.