Moreover, their mutations were also reported in LFS families and paediatric patients with similar tumour types.3,16–18,33 Similarly, germline mutations in SDHD and VHL, two genes known to confer susceptibility to pheochromocytoma, were found in both patients with this diagnosis (Fig. 3a). This evidence concerns the gene SDHD and hereditary pheochromocytoma-paraganglioma.