SSN6 is a repressor of gene expression in Saccharomyces cerevisiae27, TTC3 is an E3 ligase that binds to AKT and induces the latter’s proteasomal degradation within the nucleus28, and TTC4 is a putative tumor suppressor during melanocyte transformation and is involved in DNA replication29,30. The gene discussed is AKT1; the disease is neoplasm.