SRSF3 also regulates FoxM1 transcripts (Forkhead box transcription factor M1, transcriptional regulator involved in regulation of cell cycle and proliferation), and the transcriptional targets of FOXM1 including Cdc25B (member of CDC25 family of phosphatases, required for mitosis) and PLK1 (Polo like kinase 1, highly expressed during mitosis, and frequently elevated in cancers) to control cell cycle progression and proliferation. This evidence concerns the gene PLK1 and cancer.