For instance, RIP-Seq analysis in lymphoma cells indicated that nuclear eIF4E binds over 3000 mRNAs that encode proteins acting in lymphoma-sustaining pathways such as B-cell receptor signaling (Bcl2, Bcl6) and DNA methylation/epigenetic regulation (DNMT1, DNMT3A, HDAC1) (Culjkovic-Kraljacic et al., 2016). This evidence concerns the gene BCL2 and lymphoma.