Disrupted RBP activity has been reported for nearly every step of mRNA metabolism including splicing (such as U2AF1, SRS2, ZRSR2, SR3B1, SRSF3), export (including THO, ALYREF, Luzp4, GANP, CRM1, eIF4E, SRSF3, UNR), nuclear pore (e.g., Nup88, Nup96/98, Nup214, TPR), and translation (eIF4E, UNR, eIF4A, eIF3), etc., Interestingly, mutations in spliceosome factors are frequent in hematological malignancies but rare in solid tumors (Dvinge et al., 2016; Carey and Wickramasinghe, 2018), highlighting their contextual importance in driving specific pathways in malignant transformation. This evidence concerns the gene ALYREF and hematologic disorder.