Of particular interest, dermal and hypodermal adipose tissue progressively disappeared during the whole process, as reported in the bleomycin model (21) and in human SSc (22), where it has been speculated that adipocyte attrition could even contribute to fibrogenesis through a putative adipocyte-to-fibroblast switch under PPAR-γ deregulation (23). This evidence concerns the gene PPARG and systemic sclerosis.