Another fact supporting the concept that IL-1β has limited intestinal proinflammatory capability is that patients with autoinflammatory syndromes [patients with CAPS (cryopyrin-associated periodic syndrome)] that manifest a lowered threshold of NLRP3 activation and produce IL-1β without a second signal only rarely manifest intestinal inflammation. The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.