Another genetic disorder leading to increased NLRP3 inflammasome activity in the intestine involves an abnormality in the function of tyrosine phosphatase non-receptor 22 (PTPN22), an enzyme that dephosphorylates NLRP3 at Tyr859 (in mice) and Tyr861 (in humans) (42). This evidence concerns the gene NLRP3 and hereditary disease.