NLRP3 and hyperinsulinemic hypoglycemia, familial, 4: A less esoteric setting of NLRP3 hyperactivity is colitis occurring in the presence of IL-10 deficiency which is due to the fact that IL-10 has the unique ability among commonly produced cytokines to inhibit the NLRP3 inflammasome and thus to cause hyperactivity of this inflammasome in its absence (33) (see Figure 1).