Likewise, Catalan and colleagues showed increased release of pro-inflammatory and angiogenesis-related factors (lipocalin-2, chitinase 3-like 1, TNF-α, osteopontin, HIF-1α, VEGF), as well as increased MMP9 enzymatic activity in VAT of overweight subjects affected by CRC (52). The gene discussed is VEGFA; the disease is colorectal carcinoma.