Thus, SLAMF7 does not have activation or inhibitory signaling function in myeloma cells, due to the lack of EAT-2 to mediate activation and the lack of CD45 to maintain Src family kinases in an active state that is required to phosphorylate SLAMF7 and the inhibitory SHIP-1 phosphatase. The gene discussed is SLAMF7; the disease is plasma cell myeloma.