CD4 and arthritic joint disease: For example, Bailey-Bucktrout et al. (38) showed that murine Treg with demethylated TSDR down-regulated FOXP3 transcription in the inflamed CNS, while Bending et al. (39) revealed that demethylation of these regions was decoupled from stable FOXP3 expression in a subset of CD4+CD127lowCD25hi human T cells that were increased in the more severe forms of arthritis.