Clinical relevance of IL-22 in IBD pathogenesis has been established given that some pronounced IBD risk genes, such as Il-23, Stat3, Jak2, Tyk2, Fut2, are involved in IL-22-STAT3 signaling, and that enhancing IL-22 pathway can improve mucosal healing and ameliorate disease progression (10). This evidence concerns the gene JAK2 and inflammatory bowel disease.