IL22 and inflammatory bowel disease: In light of a recent microarray analysis showing up-regulation of ATF3 in patients with active IBD (21), while lacking evidence supporting a role for ATF3 in intestinal homeostasis and IBD pathogenesis, we have performed in-depth analyses here, using primary intestinal organoids and animal models, to reveal how ATF3 is acting as a critical downstream regulator of the IL-22 signaling cascade in intestinal epithelial cells.