ADAM17 and colorectal adenocarcinoma: Figure 1A shows that, when stimulated with phorbol ester PMA and divalent cation Mn2+ (a potent activating agent that induces integrin high affinity state), Colo320 (colorectal adenocarcinoma), LoVo (colorectal adenocarcinoma) and SKOV-3 (ovarian carcinoma) cancer cells readily and specifically adhered to a substrate coated with ADAM17-Fc.