ADAM17 and neoplasm: We have demonstrated that treatment with mAb 2A10 or expression of CD9 on the cell surface specifically abrogates the α5β1-mediated adhesion of different types of tumor and leukocytic cells both to its canonical ligand Fn and also to its alternative ligand ADAM17-Fc, a recombinant protein which encompasses all the domains of the extracellular region of human ADAM17 (pro-, catalytic-, disintegrin- and membrane proximal-domain) fused to the Fc constant region of human IgG.