TNF and obesity due to melanocortin 4 receptor deficiency: The co-administration with polysaccharide inulin improved the utilization of rutin and further increased the production of butyrate and reduced the expression of the key inflammatory cytokine TNF-α, indicating the polyphenol rutin and polysaccharide inulin can be utilized combinatorially as a dietary strategy to ameliorate gut dysbiosis and inflammation associated with HF-induced obesity.