Primary biliary cholangitis (PBC) is a rare, immune-mediated cholestatic liver disease (Selmi et al., 2011; Hirschfield and Gershwin, 2013; Beuers et al., 2015; Webb and Hirschfield, 2017), mostly affecting women, with the following features: cholestasis, serologic reactivity to antimitochondrial antibodies (AMA) or specific antinuclear antibody (ANA) reactivity, and histological evidence of chronic non-suppurative, granulomatous, lymphocytic small bile duct cholangitis. Here, BTG3 is linked to primary biliary cholangitis.