HSF1 and Hepatic fibrosis: The purposes of this study were as follows: (1) to test whether the signaling mechanisms underlying the ER stress inhibition effects are associated with the SIRT1/HSF1 pathway in BDL-induced liver fibrosis; (2) to study whether SalA inhibits ER stress by up-regulating SIRT1; and (3) to explore the role of the ER stress inhibition effect of SalA in protecting against BDL-induced liver fibrosis.