APOE and Alzheimer disease: This finding corroborates previous data showing that the Aβ aggregation-preventing compound homotaurine exerts protective effects on AD in conditions of APOE ε4 genotype (Caltagirone et al., 2012) and in the early stages of the disease, as holding a positive effect on hippocampus atrophy and short-term episodic memory loss in amnestic MCI patients (Spalletta et al., 2016).