HTT and Huntington disease: Despite the high similarity of SOCE machinery in MSNs and SK-N-SH (Wu et al., 2011; Czeredys et al., 2013, 2017; Vigont et al., 2014), various mechanisms of SOCE regulation in different HD cellular models may result in distinct disturbances caused by the HAP1A-mutant HTT-IP3R1 complex.