In contrast, we did not found significant differences as regards the phenotypic profile of PB vs. BM TPC for other maturation-associated antigens previously described to be aberrantly expressed by TPC in MM and MGUS patients, such as CD19, CD20, CD45 and sm/cyIg;49,62 this might be due to the fact that the pattern of expression of these markers could more closely reflect tumor phenotypes potentially associated with specific genetic lesions -e.g., CD20 expression in cases carrying t(11;14)-70 than actual maturation-associated phenotypes. Here, CD19 is linked to Miyoshi myopathy.