Similarly to rescued shG9a adenocarcinoma cells (Fig. 3f), we observed significant downregulation of the G9a targets Sca-1 and Mmp10 (Fig. 4f), suggesting that Kdm3a depletion may impede TPCs through the same mechanisms as G9a expression in lung adenocarcinoma cells. This evidence concerns the gene KDM3A and adenocarcinoma.