The present study focused on rs1799971, rs563649 and rs1323040 loci of the OPRM1 gene and rs2032582, rs1045642 and rs1128503 loci of the ABCB1 gene, and we found that the SNPs at rs1799971 and rs1323040 loci of OPRM1 and rs2032582 and rs1128503 loci of ABCB1 were significantly correlated with sufentanil consumption in patients who underwent radical resection of lung cancer. The gene discussed is OPRM1; the disease is lung cancer.