For the first time, our study evaluated the correlation between SNPs at the rs1799971, rs563649 and rs1323040 loci in OPRM1 and the rs2032582, rs1045642 and rs1128503 loci in ABCB1 with sufentanil consumption in Chinese Han patients who underwent radical resection of lung cancer. The gene discussed is OPRM1; the disease is lung carcinoma.