Our study is the first to evaluate the correlation between SNPs at the rs1799971, rs563649 and rs1323040 loci in the OPRM1 gene and the rs2032582, rs1045642 and rs1128503 loci in the ABCB1 gene with sufentanil consumption in Chinese Han patients who underwent radical resection of lung cancer. This evidence concerns the gene OPRM1 and lung cancer.