桥接整合因子-1(bridging integrator-1, BIN1)是一种MYC适配体蛋白,具有抑癌特性[35]。BIN1在NSCLC的EGFR突变细胞株中表达降低或缺失,而PD-L1在BIN1过表达后明显下降,敲低BIN1后PD-L1表达明显上调。无论体外还是体内实验均证实BIN1的过表达可使EGFR/MAPK信号通路失活从而抑制和调控PD-L1介导的免疫逃逸[36]。. This evidence concerns the gene CD274 and non-small cell lung carcinoma.