We were able to show differences for the activated/phosphorylated kinases MEK1/2, p40/p42 MAPK1 and MAPK2 (ERK1/2), and GSK-3β in brain protein lysates from female DNA Aβ42-immunized mice compared with the age- and gender (female)-matched 3xTg-AD control mice, supportive of the assumption that a higher removal of Aβ oligomers after DNA Aβ42 trimer immunization has significant effects on tau pathology via changes on cellular kinases. Here, GSK3B is linked to Alzheimer disease.