MAP2K1 and Alzheimer disease: Figure 7 shows the detection MEK1/2 and phospho-MEK1/2 (Fig. 7a), as well as ERK1/2 and phosphorylated ERK1/2 (Fig. 7b), in brain lysates from seven DNA Aβ42-immunized mice compared with seven age- and gender-matched 3xTg-AD control mice and two 20-month-old wild-type mice.