IL4 and Alzheimer disease: ELISPOT assays from splenocyte cultures of 3xTg-AD mice and wild-type mice were performed to detect IFN-γ (Th1 cytokine), IL-17A (Th17 cytokine), and IL-4 (Th2 cytokine) upon Aβ42 peptide restimulation in the immunized mice.