MAPT and Alzheimer disease: For pT181 tau, mean levels of 3.869 × 104± 1.774 × 104 pg/mg in the detergent-soluble brain lysates of 3xTg-AD control mice were reduced to 3.098 × 104 ± 0.99 × 104 pg/mg in Aβ42 peptide-immunized mice (p = 0.3686) and to 1.969 × 104 ± 0.507 × 104 pg/mg in DNA Aβ42 trimer-immunized mice (p = 0.0198).