SEMA5A and cancer: The ability of Sema5A to enhance metastases formation in some cancer models has been ascribed to its effect on angiogenesis: in vivo Matrigel plug assays demonstrated that Sema5A promotes angiogenesis and treatment of endothelial cells with recombinant extracellular domain of Sema5A enhanced endothelial cells proliferation, through Akt pathway activation, and increased migration through Met tyrosine kinase receptor and upregulation of MMP-9 [14].