Decreased expression of Sema5A was also observed in the BV173 human chronic myeloid leukemia (CML)-lymphoid blast crisis cells transduced with the same c-Myb lentiviral vector (Fig. 4e), confirming that c-Myb regulates the expression of Sema5A. The gene discussed is SEMA5A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.