By using a synthetic miR-204 we demonstrated that melanoma cells overexpressing miR-204 exhibit evident decreased levels of c-Myb together with downregulation of Sema5A, even if with less drastic affect, thus indication that, although we demonstrated for the first time the regulation of Sema5A by c-Myb and Bcl-2, other cellular factors may be involved in the regulation of Sema5A expression. Here, MYB is linked to melanoma.