SE-iFISH enables non-hemolytic elimination of red blood cells (RBCs) and depletion of white blood cells (WBCs) by anti-multiple WBC antibody, and characterizes CTCs integrated phenotyping and karyotyping of centromere probe 8 (CEP8) regardless of epithelial cell adhesion molecule (EpCAM) and cytokeratins (CKs) expression on the tumor cell surface [17, 18]. This evidence concerns the gene EPCAM and neoplasm.