CDK1 and ovarian cancer: CDK1 not only promotes G2-M transition but also regulates G1 progression and G1-S transition by binding with multiple interphase cyclins [24, 25] In ovarian cancer, the expression of CDK1 is significantly associated with survival status, histological grade, FIGO stage, lymph node metastasis, and metastasis in epithelial ovarian cancer patients [26].