The likely short longevity of naturally induced antibodies against EBA175RIII-V is contrary to the dynamics of antibodies against MSP1–19, which have been found to persist for several years after the clearance of P. falciparum parasites [53, 54] and thus may be a suitable candidate to use as a serological marker to monitor changes in malaria transmission intensity. This evidence concerns the gene ATAD1 and malaria.