MutsigCV identified ten lung adenocarcinoma associated genes: KRAS, TP53, STK11, KEAP1, SMARCA4, EGFR, RBM10, C3orf27, ZNF831, and OR5M11. Stepwise multivariate mutation-specific regression models identified a partially overlapping set of 21 cancer-associated genes: EGFR, TP53, KRAS, SI, STK11, FLG, PTPRD, COL11A1, LRP1B, FBN2, NEIL3, CSMD3, SPTA1, CDH10, PCLO, MYH1, USH2A, SPHKAP, ZNF804A, XIRP2, and ZNF831. Here, SPTA1 is linked to lung adenocarcinoma.