Figure 2 shows the multivariate predictors of VO2peak in HOCM patients. Multivariate analysis identified age (p < 0.0001), female sex (p = 0.001), a history of diabetes (p = 0.01), BMI (p < 0.0001), left atrial volume index (p = 0.04), E/e’ (p = 0.004), hemoglobin (p = 0.0004), and NT-proBNP (p < 0.0001) as significant independent predictors of the lowest VO2peak in HOCM patients. This evidence concerns the gene NPPB and diabetes mellitus.