Increased EAA in the cancer cell food based environment would imbalance nuclear signalling controls, as we showed at least at the level of poly ADP-ribose polymerase-1 (PARP-1), and this activity could trigger a cascade of events mortal for cancer cells because the elevated metabolic requirements of NEAA in cancer cells are devoted to matching both energy production and the synthesis of proteins. The gene discussed is PARP1; the disease is cancer.