Table 1 shows that total T had positive trends with the skeletal muscle mass, %TS, HDL, and sex hormone biomarkers (all p for trend <0.01). On the other hand, age (p for trend <0.05), central obesity (p for trend <0.001), visceral fat mass (p for trend <0.001), NAFLD (p for trend <0.001), MetS (p for trend <0.001), hypogonadism (p for trend <0.001), IR (p for trend <0.001), TG (p for trend <0.01), and RBC rheology (p for trend <0.05) had negative trends with total T. The gene discussed is PLXNA3; the disease is metabolic syndrome.