Patients with cirrhosis and HCC showed significantly higher median plasma levels of Annexin V-MV (i.e., phosphatidylserine+ MVs), endothelial-derived, platelet-derived, leukocyte-derived MV, as well as TF-bearing MV and thrombomodulin (TM) + MV than cirrhotic patients without HCC and healthy controls. Here, THBD is linked to hepatocellular carcinoma.