The presence of AR-V7 in circulating tumor cells from men with metastatic CRPC is not associated with primary resistance to taxane chemotherapy [23,24], which is contrary to pre-clinical data suggesting that the expression of AR-V7 mediates resistance to docetaxel in LuCap23.1 human prostate cancer xenografts [25]. The gene discussed is AR; the disease is Familial prostate cancer.