RA, as a dietary phenolic compound ingested from tea, was displayed to have anti-PCa activities by inhibiting viability, colony formation, and spheroid formation of PCa cells via HDAC2 inhibition and the consequential p53-mediated cell cycle arrest and apoptosis Therefore, RA would be used as a novel phytomedicine to act as an HDAC inhibitor targeted to PCa, with the anticipation to decrease the adverse side effects of the existing chemotherapeutical agents. This evidence concerns the gene HDAC2 and posterior cortical atrophy.