Chen et al. reported that silencing of the SOX2 gene reduces the tumourigenic potential of a lung cancer cell line (A549 cells) with downregulation of C-MYC, WNT1, WNT2, and NOTCH1 in mice; these authors uncovered 246 additional target cancer genes of SOX2 [44]. The gene discussed is WNT2; the disease is lung carcinoma.