PDGFRA and diffuse intrinsic pontine glioma: This is supported by the expression of essential factors in the specification of oligodendrocytes, PDGFRA amplification, chondroitin sulfate proteoglycan NG2, and basic helix-loop-helix transcription factors: OLIG1 and OLIG2, are up-regulated in 80% of DIPG cases [1,71,111,112].