ACVR1 and neoplasm: It is suggested that these histone mutations may contribute to an initial oncogenic event; however, are not solely sufficient for the formation of the tumour and are associated with other gene mutations such as cell cycle regulators (TP53, PPMID), the chromatin remodeler (ATRX), or growth factors (ACVR1, PDGFRA) [18,19,22,32,33,34].