Interestingly, there may be a distinct difference in the cell of origin of these tumours as it has been shown that the H3.3 K27M mutated DIPG have a proneural/oligodendroglial phenotype with a pro-metastatic gene expression signature with PDGFRA activation, while H3.1 K27M mutated tumours exhibit a mesenchymal/astrocytic phenotypic phenotype [113]. Here, PDGFRA is linked to neoplasm.