As is already evident, CCR6 and CCL20 have roles in the metastasis of advanced cutaneous T cell lymphoma (CTCL), demonstrating that CCR6 activation innervates the signal transducer and activator of transcription 3 (STAT3) pathway, mediating the transcription of CCL20, which leads to CTCL lymphomagenesis. This evidence concerns the gene STAT3 and primary cutaneous T-cell non-Hodgkin lymphoma.