Since ALL, AML (in some cases) and chronic myeloid leukemia (CML) (through BCR-ABL) are also MYC-positive, we tested whether HSP90 inhibition would downregulate MYC in the human CML cell line, K562 (Supplementary Figure S3). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.