MYCN and neuroblastoma: Interestingly, MYC has been reported to be a client of HSP90 in mantle cell lymphoma [13], and inhibition of HSP90 function has been shown to cause destabilization of MYC and NMYC proteins in neuroblastoma, which was associated with decreased tumor cell proliferation, cell cycle arrest, increased apoptosis, and upregulation of tumor suppressors, such as p53 [14].