Exploiting this notion, we found that treating human Burkitt lymphoma cell lines (Raji and CA46) with the HSP90 inhibitors, 17-AAG or 17-DMAG, decreased MYC expression levels by reducing both MYC mRNA and protein levels, subsequently diminishing tumor cell proliferation causing cell cycle arrest, and increasing necrosis and apoptosis. This evidence concerns the gene MYC and neoplasm.