Compared with wild‐type haplotype block, haplotype block CCAC including both the minor C allele of ERCC1 rs735482 and A allele of ERCC1 rs2336219 (OR = 14.323, 95%CI: 6.503‐31.547); haplotype block AAGC including the minor A allele of ERCC1 rs3212986 (OR = 17.692, 95%CI: 7.909‐39.576); haplotype block CAGT including the minor T allele of CD3EAP rs1007616 (OR = 22.646, 95%CI: 10.051‐51.026); haplotype block AAGT including both the minor A allele of ERCC1 rs3212986 and T allele of CD3EAP rs1007616 (OR = 5.000, 95%CI: 1.562‐16.005) were significantly associated with the high risk of lung cancer. This evidence concerns the gene POLR1G and lung cancer.