CD3EAP may probably be related to cell proliferation involving in the RNA polymerase I transcription complex.18, 44 In another previous study, we confirmed that co‐expression patterns were consisted in overlapping genes as ERCC1, CD3EAP, and PPP1R13L. Particularly, there was a significant association between CD3EAP exon 3 and ERCC1 exon 11, while CD3EAP exon 1 and PPP1R13L exon 1.45 The potential influence of CD3EAP expression was in response to the regulation of genetic networks known to be associated with DRC and lung cancer risk. This evidence concerns the gene ERCC1 and lung cancer.