SLC26A3 and coagulation factor 5 (F5) have both previously been identified as risk loci in IBD GWAS studies.2, 51SLC26A3, also known as the downregulated in adenoma (DRA) gene, encodes a protein essential for intestinal chloride absorption and is a transmembrane glycoprotein localized to the apical membrane of the columnar epithelium. This evidence concerns the gene SLC26A3 and inflammatory bowel disease.