Four out of four SCCs with strong phospho-Rb S249 staining (score >3) were grade 3 or higher tumors, while in AC, 2 out of 3 tumors with phospho-Rb S249 staining score >3 had a tumor grading of 3 or higher (see cores C1, C2, C5, C6, B2, B5 in TMA1 LC241c, and core B7 in TMA2 LC488 in S2 and S3 Tables). The gene discussed is RB1; the disease is neoplasm.