To confirm the association between p39, E-cadherin and phospho-Rb S249 scores, we randomly selected 70% of our SCC tumors from our TMAs and used our linear regression model to calculate tumor staging considering only the p39 score, only phospho-Rb S249 score, only E-cadherin and the three markers phospho-Rb S249, E-cadherin and p39 scores combined together. The gene discussed is CDH1; the disease is neoplasm.