Interestingly in a recent publication, increase of DNA methylation and decrease of expression for NXN has been characterized in placenta from women with diabetes during pregnancy [63] suggesting that the presence of rs623323 may influence susceptibility to type II diabetes via alteration of NXN function thus providing with a great example of how integrative QTL analysis can provide with evidence to better understand disease susceptibility. This evidence concerns the gene NXN and type 2 diabetes mellitus.